Written By: Chloe Wilson BSc (Hons) Physiotherapy
Reviewed By: SPE Medical Review Board

Pain in the palm of the hand can make even simple tasks like gripping, typing or lifting uncomfortable.
Whether palm pain develops gradually or suddenly, it usually indicates irritation, inflammation or injury to the soft tissues, nerves or hand bones.
Palm pain often occurs alongside stiffness, weakness, tingling or reduced grip strength. In some cases, symptoms may extend into the fingers or wrist, leading to combined pain in wrist and palm.
In this guide, we will explore the most common causes of pain in palm of hand, how to recognise them, and what to do next. If your pain is in a different part of your hand, check out our hand pain diagram for help working out what is wrong.
The most common causes of hand pain on the palm can be grouped based on the type of tissue involved:
Understanding which category your symptoms fall into can help narrow down the likely cause of your pain in palm of hand and guide the next steps for treatment.
Carpal tunnel syndrome is one of the most common causes of pain in the wrist and palm. It occurs when the median nerve becomes compressed as it passes through the carpal tunnel at the front of the wrist.
Common symptoms of Carpal Tunnel Syndrome include:

Typical causes:
Find out more about the causes and treatment options in our full guide on Carpal Tunnel Syndrome.
Trigger finger occurs when one of flexor tendons becomes irritated and inflamed, making it difficult for the finger to glide smoothly. It most typically develops in the thumb, middle or ring finger.
Common symptoms of Trigger Finger include:

Typical causes:
You can find out all about the causes, symptoms and best treatment options for this cause of pain in palm of hand in the Trigger Finger section.
A ganglion cyst is a fluid-filled lump that often develops near the wrist joint and can cause pain in wrist and palm if it presses on nearby structures.
Ganglion cysts are the most common cause of a lump on palm.
Common symptoms of ganglion cysts are:

Typical causes:
You can find out more about the causes and best treatment options in the Ganglion Cysts section.
Another common cause of hand pain on the palm is Dupuytren’s Contracture that may affect one or both hands.
Dupuytren’s contracture causes thickening of the connective tissue in the palm, leading to lumps or cords that can pull the fingers into a bent position.
Common symptoms of Dupuytren’s Contracture include:

Typical causes:
Find out more about the causes and treatment options in the Dupuytren’s Contracture section
Flexor tendonitis is caused by inflammation of the tendons that bend the fingers. It is a frequent cause of palm pain, particularly in people who perform repetitive gripping activities.
Common symptoms of flexor tendonitis include:

Typical causes:
Find out more about the common causes and treatment options for Flexor Tendonitis.
A fracture in one of the hand bones can cause significant pain in palm of hand, usually following trauma such as a fall or punching something.
Common symptoms:
Typical causes:
The most common hand bone to break is the 5th metatarsal, but any of the hand bones can be broken. Find out more about the common causes and treatment options for hand fractures.
Nerve-related conditions can cause hand pain on the palm along with tingling, burning or numbness.
Common symptoms of nerve problems include:
Possible causes:
Find out more about how nerve problems cause hand pain on palm in the Arm Nerve Pain article.
While less common, there are some other conditions that can cause palm pain, including:
If your palm pain symptoms are unusual, severe or not improving, further investigation may be needed.
You should seek medical advice if your pain in palm of hand is:
Early diagnosis helps prevent long-term complications and speeds up recovery from palm pain.
Treatment for hand pain on palm depends on the underlying cause, but the good news is that most cases improve with simple conservative measures.
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Targeted exercises under the guidance of a physical therapist can restore movement, reduce stiffness and prevent recurrence:
If symptoms persist or worsen, further treatment may be needed for pain in the palm of the hand:
Surgery for hand pain on palm is usually only considered when other treatments haven’t worked, or symptoms are severe:
Most cases of palm pain settle within a few weeks with the right approach. Early treatment and addressing the underlying cause are key to a faster and more complete recovery.
The exact location of your symptoms is often the biggest clue to what is causing your pain in the palm of your hand.
Pain at the base of the fingers is most commonly linked to tendon problems such as trigger finger or flexor tendonitis.
Pain in the centre of the palm may indicate soft tissue changes like Dupuytren’s contracture or, less commonly, palmar fasciitis.
Pain between the wrist and palm is often caused by nerve compression, such as carpal tunnel syndrome, or pressure from a ganglion cyst.
Deep, widespread or sudden palm pain, especially after an injury, may suggest a fracture or more serious tissue damage.
Identifying the underlying cause is key to effective treatment. Most cases of hand pain on palm settle with simple measures, but persistent or severe symptoms should always be assessed by a healthcare professional.
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Page Last Updated: April 29th, 2026
Next Review Due: April 29th, 2028